North Carolina Wesleyan has had several student-athletes across a variety of sports earn All-American accolades, both athletically and academically.
| BASEBALL | ||
| Greg Clark | '81 | |
| Carl Payne | '83, '85 | |
| Richard Mattocks | '83 | |
| Steve Durelli | '84, '85 | |
| Gene Sanguinetti | '85 | |
| Charlie Simpson | '85 | |
| Frankie Moore | '86, '87 | |
| Paul Prisco | '86, '87 | |
| James Anderson | '87 | |
| Mark Silletti | '88 | |
| Doug Flowers | '88, '90 | |
| Erik Dube | '89 | |
| Eric Jarman | '90 | |
| Rich McNee | '92 | |
| Troy Yeager | '93 | |
| Tom D'Aquila | '93, '94 | |
| Tim Kemp | '94 | |
| Wes Pratt | '94 | |
| Chris Bryant | '94, '95 | |
| Marvin Johnson | '95 | |
| Mike Abbruzzese | '97 | |
| Jeremy Stewart | '97 | |
| Jon Rardin | '98 | |
| Matt McCay | '98 | |
| Jayson Sigley | '99 | |
| Blake Rice | '06 | |
| Matt Smith | '07, '08 | |
| Davie Morgan | '22 | |
| Payne Stolsworth | '23 | |
| MEN'S BASKETBALL | ||
| Roger Taylor | '70 | |
| Paul Hess (academic) | '81 | |
| Keith Jones (academic) | '81 | |
| Marquis McDougald | '99 | |
| Jamar Jones | '00 | |
| Chris Moody | '00 | |
| Bradley Blue | '03 | |
| Trey Drake | '10 | |
| Brandon Givens | '13 | |
| Damon McDowell | '21 | |
| WOMEN'S BASKETBALL | ||
| Priscilla Rickenbacker | '81 | |
| Rita Johnson | '82 | |
| Rose Edmonds | '85 | |
| Robin Brooks | '87 | |
| Sharon McLeod | '91 | |
| Misty Carneal | '02 | |
| FOOTBALL | ||
| LeeRon Boykin | '07, '09 | |
| Tazmon Foster | '11 | |
| Kevin Quicker | '11 | |
| Dwayne Hollis | '11, '12 | |
| Jacques Alston | '14 | |
| Malik Adams | '15 | |
| Martin Brazwell | '15 | |
| Dustin Midgett | '15 | |
| Eddie Graham | '19 | |
| Antonio Johnson | '20 | |
| MEN'S SOCCER | ||
| Scott Preston | '85 | |
| Bill Tully | '86 | |
| Greg Armand | '86, '87 | |
| Ken Bowers | '88 | |
| Taher Husain (academic) | '88 | |
| Marco Kirsch | '07 | |
| Danny Persson | '08 | |
| Baboucarr Njie | '19 | |
| WOMEN'S SOCCER | ||
| Julie Dueler | '91, '92, '93 | |
| Trish Parker | '93 | |
| Alyson Patrick | '96 | |
| Kim Olsen | '97 | |
| Jennifer Foreman | '99 | |
| Alexa Kapetanakis | '99 | |
| Caitlin Sanderson | '00 | |
| SOFTBALL | ||
| Ashlee Bass | '06 | |
| MEN'S TENNIS | ||
| Rinat Khussainov | '12 | |
| Alexey Rumyantsev | '12 | |
| Robert Kjellberg | '12, '13, '14, '15 | |
| Artsiom Prostak | '13 | |
| Johan Ljungdahl | '13, '14 | |
| Sebastian Sikh | '15, '18 | |
| Robert Puig | '21 | |
| Jhonny Acosta | '22 | |
| John Falke | '23 | |
| Women's Tennis | ||
| Kristal Dule | '23 | |
| Women's Track & Field | ||
| Ahnia Cherry | '23 |